|
Test Sensitivity
Solutions' RB1 tests were developed from the retinoblastoma research program funded by
the Canadian Genetic Diseases Network (CGDN), a National Centre of Excellence.
Our lab's test sensitivity is shown below, based on almost 900 families analyzed to date:
Sensitivity to Detect Unknown RB1 Mutations
| |
Analyzed |
Found Mutation |
M in Blood |
M Not Found |
Sensitivity |
| Bilaterals |
431 |
407 |
|
24 |
94.4% |
| Unilaterals with positive family history |
27 |
24 |
|
3 |
88.9% |
| Total Known Germline |
458 |
431 |
|
27 |
94.1% |
| Unilaterals, No Known Family History |
404 |
374 |
67 |
30 |
92.6% |
| Total Families Analyzed |
862 |
805 |
Overall Sensitivity: |
93.4% |
Data Last Updated:
July 31, 2008 |
|
Mutations Yet to be Diagnosed: |
6.6% |
|
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