Test Sensitivity

Solutions' RB1 tests were developed from the retinoblastoma research program funded by the Canadian Genetic Diseases Network (CGDN), a National Centre of Excellence.

Our sensitivity is calculated only for individuals known to have a family history, or for whom a viable tumor sample is available. Nonetheless, when no viable tumor sample is available for unilaterally affected individuals, our lab also analyzes blood samples only for RB1 mutations. Contact us for more details.

Our lab's test sensitivity, based on over 1000 families analyzed to date:

Sensitivity to Detect Unknown RB1 Mutations

 

Analyzed

Found Mutation(s)

M in Blood

M Not Found

Sensitivity

Bilaterals

510

484

 

26

94.9%

Unilaterals with positive family history

30

28

 

2

93.3%

Total Known Germline

540

512

 

27

94.8%

Unilat's, No Family History, with Tumor

514

483

74

31

94.0%

Total Families Analyzed

1054

995

Overall Sensitivity:

94.4%

Data Last Updated:
January 19, 2010

 

Mutations Yet to be Diagnosed:

5.6%